Spring to Life | Post Test S2L - Post Test Optimal strategies for treating PCNSL at the time of relapse include all of the following: * Re-challenge with MTX-based regimen and ASCT Surgery followed by palliative radiation Use of immunomodulating agents in combination with other targeted agents Re-challenge with MTX and BTK inhibitor A 55-year-old male received a heart transplant at an academic center 4 months ago. He was EBV-negative serologically. The donor was EBV-positive. He is referred to a local hematology clinic for anemia.What is this patient's risk of post-transplant lymphoproliferative disorder in the next 5 years? * < 1% 5% 10% 11-20% 20-30% Polatuzumab vedotin in combination with R-CHP (R-pola-CHP) was compared to R-CHOP for initial therapy of diffuse large B-cell lymphoma in the POLARIX Trial. Which of the below is true about this study? * Overall survival was superior with R-pola-CHP when compared with R-CHOP There was less toxicity with R-pola-CHP when compared with R-CHOP Progression-free survival was superior with R-pola-CHP when compared with R-CHOP Overall survival was superior with R-CHOP compared with R-pola-CHP A 29-year-old man presents with stage IIIB Hodgkin lymphoma, IPS 1 (risk factor=male). You are considering treatment with ABVD (as per RATHL) or BV-AVD (as per ECHELON-1). Which of the following should factor into your treatment decision? * Baseline metabolic tumor volume is >220ml The patient is a professional violinist The patient has a mediastinal mass measuring 8.3 cm Circulating tumor DNA indicates an increased copy number of 9p24.1 - 52-year-old man, healthy, developed right groin discomfort. No other symptoms, PS 1. CT abd/pel: right inguinal, retroperitoneum lymphadenopathy. PET scan: diffuse FDG avid neck, mediastinum, retroperitoneum, proper inguinal LAN; SUVmax 17 - WBC 10.5 (neutrophils 9.0), Hb 13.6, platelets 428; LDH elevated. - Core biopsy of left inguinal lymph node: ALK- ALCL, FISH studies negative for DUSP22 and P63 rearrangements - Stage 3, IPI 2 ALK-ALCL What is your initial treatment recommendation? * CHOP x 6 BV-CHP x 6 CHEP-BV x 6 + maintenance BV CHOEP x 6 Which of the following is not true regarding Burkitt lymphoma? * Burkitt lymphoma is characterized by rearrangement involving the MYC gene on the long arm of chromosome 8 (8q24) NCCN guideline supports chemoimmunotherapy followed by autologous stem cell transplant as a frontline treatment option for patients with Burkitt Lymphoma Epstein-Barr virus is linked to the endemic variety of Burkitt Lymphoma. R-CODOX-M/R-IVAC, DA- R-ECOCH, and R-HyperCVAD are commonly used regimens to treat Burkitt lymphoma. Which of the following is NOT commonly associated with the intestinal T-cell lymphomas EATL and MEITL? * Celiac disease Campylobacter jejuni Small bowel obstruction Intestinal perforation Parenteral or enteral nutrition requirement In high-grade B-cell lymphoma (HGBCL) with BCL2/MYC rearrangements: * A low KI-67 proliferation index excludes the diagnosis. oBCL6 rearrangement analysis is necessary for proper classification. oA DLBCL morphology with BCL6 rearrangement, in the absence of BCL2/MYC rearrangements, should be classified as HGBCL-NOS. Expression of TdT by IHC can be seen in a minority of cases. The presence of BCL2/MYC rearrangements by FISH is sufficient to diagnose HGBCL with BCL2/MYC rearrangements. The two major thrombotic microangiopathies, TTP and aHUS, are often clinically indistinguishable but require different interventions. Which of the following best characterizes aHUS? (Select all that apply) * ADAMTS13 activity <5-10% serum creatinine >1.7 Median platelet count >30,000. median platelet count <20,000 Elevated INR and PTT. A geriatric assessment consists of the following domains except * Functional status Psychological health Caregiver health Nutrition Cognition If you are human, leave this field blank. Submit Δ
